pgsk (Santa Cruz Biotechnology)
Structured Review

Pgsk, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 303 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pgsk+3%CE%B2/p-GSK-3%CE%B2+Antibody/pmc12362930-65-56-57
Average 96 stars, based on 303 article reviews
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1) Product Images from "The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells"
Article Title: The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells
Journal: Cardiovascular Diabetology
doi: 10.1186/s12933-025-02828-z
Figure Legend Snippet: Effect of the TZPD application on the cellular resting level of Ca 2+ and protein levels of parameters played roles in cellular Ca 2+ regulation via β-AR signaling. The cellular resting level of Ca 2+ was imagined in all groups of H9c2 cells loaded with a Ca 2+ -sensitive fluorescence dye Fluo-3 AM ( A ). The representative flow cytometry data demonstrate the effect of TZPD (40 nM) on intracellular Ca 2+ distribution in resting cells with and without receptor antagonism for the SC group of cells and HG group of cells (left). The average cellular Ca 2+ level in Fluo-3 AM loaded H9c2 cells was measured in all groups by the flow cytometer technique (right). The protein levels of phosphorylated PKA (pPKA) and PKA and their ratios ( B ), and phosphorylated GSK (pGSK) and GSK and their ratios ( C ), compared to a reference protein GAPDH in the SC, SC + TZPD, SC + TZPD + ANT or HG, HG + TZPD, HG + TZPD + ANT comparison to the NC group. All shortenings are the same as given in previous figures. Representative protein bands are given in the left parts of the bar graphs. Data are presented as means ± SEM. The comparisons between the two groups are performed by t-test. * p < 0.05 vs. NC group, γ p < 0.05 vs. SC group, δ p < 0.05 vs. HG group, Ψ p < 0.05 vs. SC + ANT + TZPD group, τ p < 0.05 vs. HG + ANT + TZPD group ( n = 4 for flow cytometry experiments and n = 3 for western blotting experiments)
Techniques Used: Fluorescence, Flow Cytometry, Comparison, Western Blot
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